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Updated: Jun 12, 2026

Two- and Three-Dimensional Live Cell Imaging of DNA Damage Response Proteins
10:24

Two- and Three-Dimensional Live Cell Imaging of DNA Damage Response Proteins

Published on: September 28, 2012

E2F-1 regulation by an unusual DNA damage-responsive DP partner subunit.

L Ingram1, S Munro, A S Coutts

  • 1Laboratory of Cancer Biology, Department of Clinical Pharmacology, University of Oxford, Old Road Campus Research Building, Old Road Campus, off Roosevelt Drive, Oxford, OX3 7DQ, UK.

Cell Death and Differentiation
|June 19, 2010
PubMed
Summary

DP-4, a novel protein, unexpectedly regulates E2F-1 activity during DNA damage response. This new pathway, independent of pRb, involves DP-4 binding to E2F-1, inhibiting its activity and preventing apoptosis.

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