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Radiosynthesis, Quality Control, and Small Animal Positron Emission Tomography Imaging of 68Ga-Labelled Nano Molecules
Published on: October 4, 2024
Positron emission tomography tracers for imaging angiogenesis
Roland Haubner1, Ambros J Beer, Hui Wang
1Department of Nuclear Medicine, Medical University Innsbruck, Austria. Roland.Haubner@i-med.ac.at
Abstract:
Position emission tomography imaging of angiogenesis may provide non-invasive insights into the corresponding molecular processes and may be applied for individualized treatment planning of antiangiogenic therapies. At the moment, most strategies are focusing on the development of radiolabelled proteins and antibody formats targeting VEGF and its receptor or the ED-B domain of a fibronectin isoform as well as radiolabelled matrix metalloproteinase inhibitors or alpha(v)beta(3) integrin antagonists. Great efforts are being made to develop suitable tracers for different target structures. All of the major strategies focusing on the development of radiolabelled compounds for use with positron emission tomography are summarized in this review. However, because the most intensive work is concentrated on the development of radiolabelled RGD peptides for imaging alpha(v)beta(3) expression, which has successfully made its way from bench to bedside, these developments are especially emphasized.
Insights
Positron emission tomography (PET) imaging visualizes angiogenesis, aiding personalized anti-angiogenic therapy. Radiolabeled RGD peptides for alpha(v)beta(3) integrin imaging are particularly emphasized due to their clinical success.
Area of Science:
- Molecular imaging
- Oncology
- Radiochemistry
Background:
- Angiogenesis imaging using Positron Emission Tomography (PET) offers non-invasive insights into molecular processes.
- This approach is crucial for personalized treatment planning of anti-angiogenic therapies.
Purpose of the Study:
- To review current strategies for developing radiolabeled compounds for PET imaging of angiogenesis.
- To highlight advancements in tracers targeting key molecular structures involved in angiogenesis.
Main Methods:
- Focus on radiolabeled proteins, antibody formats targeting VEGF and its receptor, ED-B fibronectin, matrix metalloproteinase inhibitors, and alpha(v)beta(3) integrin antagonists.
- Emphasis on the development of radiolabeled RGD peptides for alpha(v)beta(3) integrin imaging.
Main Results:
- Multiple strategies are being pursued for developing suitable PET tracers.
- Radiolabeled RGD peptides for alpha(v)beta(3) integrin imaging show significant progress from research to clinical application.
Conclusions:
- PET imaging of angiogenesis is a promising tool for guiding anti-angiogenic treatments.
- Development of targeted radiotracers, especially RGD peptides, is advancing the field towards clinical utility.
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