Positron emission tomography tracers for imaging angiogenesis.

Area of Science:

• Molecular imaging
• Oncology
• Radiochemistry

Background:

• Angiogenesis imaging using Positron Emission Tomography (PET) offers non-invasive insights into molecular processes.
• This approach is crucial for personalized treatment planning of anti-angiogenic therapies.

Purpose of the Study:

• To review current strategies for developing radiolabeled compounds for PET imaging of angiogenesis.
• To highlight advancements in tracers targeting key molecular structures involved in angiogenesis.

Main Methods:

• Focus on radiolabeled proteins, antibody formats targeting VEGF and its receptor, ED-B fibronectin, matrix metalloproteinase inhibitors, and alpha(v)beta(3) integrin antagonists.
• Emphasis on the development of radiolabeled RGD peptides for alpha(v)beta(3) integrin imaging.

Main Results:

• Multiple strategies are being pursued for developing suitable PET tracers.
• Radiolabeled RGD peptides for alpha(v)beta(3) integrin imaging show significant progress from research to clinical application.

Conclusions:

• PET imaging of angiogenesis is a promising tool for guiding anti-angiogenic treatments.
• Development of targeted radiotracers, especially RGD peptides, is advancing the field towards clinical utility.