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Related Concept Videos

Smallpox01:24

Smallpox

Smallpox is a severe contagious disease caused by the Variola major virus, a double-stranded DNA member of the Poxviridae family.Variola major transmission occurs primarily via inhalation of virus-laden droplets or direct contact with infectious scabs. The incubation period averages approximately seven days, although it may range from 7 to 17 days depending on the inoculum and host factors.Clinically, the prodromal phase is marked by an abrupt onset of high fever, malaise, headache, and myalgia.
Chickenpox01:20

Chickenpox

Chickenpox is an acute, highly contagious disease caused by the varicella-zoster virus (VZV), a double-stranded DNA virus belonging to the Herpesviridae family. Its transmission occurs primarily through the inhalation of respiratory droplets or direct contact with vesicular fluid from skin lesions. The incubation period typically ranges from 10 to 21 days, during which the virus replicates and disseminates through sequential phases within the host. Although generally self-limiting in children,...
Poliomyelitis01:17

Poliomyelitis

Poliomyelitis is caused by poliovirus, a small, non-enveloped, positive-sense RNA virus of the Picornaviridae family and Enterovirus genus. Transmission occurs primarily via the fecal-oral route, often through ingestion of contaminated water or food. The virus initially replicates in the oropharynx and intestinal mucosa, particularly in lymphoid tissues such as the tonsils, Peyer’s patches, and regional lymph nodes. Primary viremia follows, allowing dissemination throughout the body.In most...
Rocky Mountain Spotted Fever01:26

Rocky Mountain Spotted Fever

Rocky Mountain Spotted Fever (RMSF) is a severe tick-borne illness caused by Rickettsia rickettsii, a Gram-negative, coccobacillary bacterium. This pathogen is an obligate intracellular parasite, requiring a host cell for replication. Transmission occurs through the bite of an infected tick. In the United States, the most important vectors are Dermacentor variabilis (American dog tick) and Dermacentor andersoni (Rocky Mountain wood tick), though other tick species may also serve as vectors.
Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...

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Basophil Activation Test for Investigation of IgE-Mediated Mechanisms in Drug Hypersensitivity
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[The battle against smallpox in Austria].

Heinz Flamm1, Christian Vutuc

  • 1Emeritierter Vorstand des Klinischen Institutes für Hygiene, Universität Wien, Wien, Austria.

Wiener Klinische Wochenschrift
|June 19, 2010
PubMed
Summary

Austria

Area of Science:

  • Medical History
  • Epidemiology
  • Public Health

Background:

  • Smallpox activities in Austria began with variolation, a risky artificial infection.
  • Edward Jenner's cowpox vaccination was adopted in Lower Austria in 1800, a first for continental Europe.
  • Early vaccination involved human-to-human inoculation.

Purpose of the Study:

  • To describe the historical development of smallpox vaccination in Austria.
  • To trace the evolution of smallpox control measures from variolation to mass vaccination.
  • To document the cessation of smallpox vaccination in 1981.

Main Methods:

  • Historical review of vaccination practices in Austria.
  • Analysis of the transition from variolation to cowpox vaccination.

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  • Chronological description of smallpox vaccination programs.
  • Main Results:

    • Austria initiated smallpox control with variolation.
    • Lower Austria pioneered mass vaccination using cowpox in 1800.
    • Vaccination practices evolved from human inoculation to established programs.

    Conclusions:

    • The study details the progression of smallpox vaccination in Austria.
    • It highlights Austria's early adoption of effective vaccination strategies.
    • The paper covers the complete history of smallpox vaccination up to its discontinuation in 1981.