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Related Concept Videos

Improving Translational Accuracy02:07

Improving Translational Accuracy

Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...
Improving Translational Accuracy02:07

Improving Translational Accuracy

Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...
Ribosome Profiling02:24

Ribosome Profiling

Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences the mRNAs protected by ribosomes to get an insight into a cell’s translation landscape at any given point in time.
Applications of ribosome profiling
Ribosome profiling has many applications, including in vivo monitoring of translation inside a particular organ or tissue type and quantifying new protein synthesis levels.
The technique helps...
Genomics02:02

Genomics

Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
Translational Regulation01:29

Translational Regulation

Translational regulation in prokaryotes ensures efficient protein synthesis by controlling ribosome access to mRNA. This regulation is mediated by secondary RNA structures, including translational riboswitches, RNA thermometers, and small RNAs (sRNAs), which respond to intracellular and environmental signals to modulate gene expression.Translational RiboswitchesRiboswitches in the leader region of mRNAs can regulate translation by altering the accessibility of the Shine-Dalgarno (SD) sequence,...

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A Bioinformatics Pipeline for Investigating Molecular Evolution and Gene Expression using RNA-seq
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Building a program in translational genomics.

Jennifer L Hall1

  • 1Lillehei Heart Institute, 312 Church Street, Minneapolis, MN 55455, USA. jlhall@umn.edu

Journal of Cardiovascular Translational Research
|June 19, 2010
PubMed
Summary
This summary is machine-generated.

This article defines translational genomics and highlights the importance of establishing programs. It details the clinical, research, and consumer benefits of translational genomics initiatives.

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Area of Science:

  • Genomics
  • Translational Science

Background:

  • Translational genomics bridges the gap between genomic discoveries and clinical applications.
  • There is a growing need to integrate genomic data into healthcare and research settings.

Purpose of the Study:

  • To define translational genomics.
  • To assess the necessity for dedicated translational genomics programs.
  • To outline the advantages of such programs from multiple stakeholder viewpoints.

Main Methods:

  • Literature review and conceptual analysis.
  • Examination of existing translational research frameworks.
  • Synthesis of perspectives from clinical, research, and consumer domains.

Main Results:

  • Translational genomics facilitates the application of genomic insights to improve patient outcomes.
  • Dedicated programs are crucial for efficient translation of genomic research.
  • Benefits include enhanced diagnostics, personalized treatments, and informed consumer engagement.

Conclusions:

  • Establishing translational genomics programs is essential for advancing precision medicine.
  • These programs offer significant value across clinical practice, scientific inquiry, and public health.
  • Further development is needed to maximize the impact of genomics in healthcare.