Related Experiment Video
Updated: Jun 12, 2026

Early Detection of Drug-Induced Renal Hemodynamic Dysfunction Using Sonographic Technology in Rats
Published on: March 11, 2016
[Serum indoxyl sulfate is a useful predictor for progression of chronic kidney disease]
Shunji Namba1, Yuko Okuda, Akiko Morimoto
1Department of Clinical Laboratory, Toho University Omori Medical Center, Ota-ku, Tokyo 143-8541, Japan. namba@med.toho-u.ac.jp
Background:
Indoxyl sulfate, an endogenous metabolite of tryptophan is normally excreted into urine. In patients with chronic kidney disease (CKD), however, the reduced indoxyl sulfate renal clearance leads to elevated indoxyl sulfate serum level. In this study we determined whether the serum levels of indoxyl sulfate are related to the progression rate of CKD stage in CKD patient.
Methods:
The association between indoxyl sulfate and progression of CKD stage was studied in 47 CKD patients (19 male, 28 female). Serum levels of IS were measured by using high performance liquid chromatography and the measured values of the study cohort were divided into quintiles.
Results:
The mean serum amount indoxyl sulfate in the healthy subject was 0.06 +/- 0.04 mg/dL (mean +/- SD). Those with indoxyl sulfate serum levels of > or = 0.3 mg/dL had a significantly progression of CKD than with <0.3 mg/dL. Especially, those patients with indoxyl sulfate serum levels of 0.47 mg/dL had the highest CKD progression.
Conclusion:
High serum levels of indoxyl sulfate are related with a progression of CKD stage in CKD patients. Thus, serum indoxyl sulfate is one of the clinical factors that affect CKD progression.
More Related Videos
Related Concept Videos
Acute Kidney Injury IV: Diagnostic Studies and Prevention
Chronic Kidney Disease I: Introduction
Acute Kidney Injury I: Introduction
Chronic Kidney Disease III: Interprofessional Care
Serum Studies: Renal Function Tests
Chronic Kidney Disease II: Clinical Manifestations

