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Medicated chewing gum--a potential drug delivery system.
Shivang A Chaudhary1, Aliasgar F Shahiwala
1National Institute of Pharmaceutical Education and Research-Ahmedabad, C/o. BV Patel Pharmaceutical Education and Research Development Center, Department of Pharmaceutics, SG Highway, Thaltej, Ahmedabad-380054, India.
Expert Opinion on Drug Delivery
|June 22, 2010
Summary
Medicated chewing gum (MCG) offers a convenient drug delivery option for all ages. This review covers MCG formulation, manufacturing, and therapeutic potential, highlighting its role in product differentiation.
Area of Science:
- Drug Delivery Systems
- Pharmaceutical Technology
- Oral Drug Delivery
Background:
- Patient convenience and compliance drive innovation in drug delivery.
- Medicated chewing gum (MCG) presents a patient-friendly dosing method for various populations.
- MCG addresses challenges for individuals with swallowing difficulties and the general populace.
Purpose of the Study:
- To review the formulation, manufacturing, and evaluation of medicated chewing gums (MCG).
- To discuss the therapeutic potential and limitations of MCG as a drug delivery system.
- To provide insights into the rationale and strategies for MCG development and performance assessment.
Main Methods:
- Comprehensive review of MCG formulation ingredients.
- Discussion of various MCG manufacturing processes.
- Assessment of in vitro and in vivo drug release studies for MCG.
Main Results:
- Readers will understand the fundamental principles of MCG formulation.
- Knowledge on prominent strategies for evaluating MCG performance will be gained.
- The review elucidates the therapeutic applications and constraints of MCG.
Conclusions:
- Directly compressible co-processed gum materials facilitate rapid, safe, and cost-effective MCG development.
- MCG formulation enables the revitalization of existing drugs and the creation of differentiated patented products.
- MCG offers a strategic advantage against generic competition.
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