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Related Experiment Video

Updated: Jun 12, 2026

Operating Procedures of the Electrochemotherapy for Treatment of Tumor in Dogs and Cats

Operating Procedures of the Electrochemotherapy for Treatment of Tumor in Dogs and Cats

Published on: October 24, 2016

Cancer electrogene therapy with interleukin-12.

Maja Cemazar¹, Tomaz Jarm, Gregor Sersa

¹Department of Experimental Oncology, Institute of Oncology Ljubljana, Zaloska 2, SI-1000 Ljubljana, Slovenia. mcemazar@onko-i.si

Current Gene Therapy

|June 22, 2010

Summary

Electrogene therapy using interleukin-12 (IL-12) DNA shows significant antitumor effects by stimulating immunity and inhibiting blood vessel growth. This promising cancer treatment is advancing into clinical trials for human and veterinary oncology.

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Area of Science:

Oncology
Immunotherapy
Gene Therapy

Background:

Electrogene therapy involves delivering plasmid DNA and applying electric pulses to tissues.
Interleukin-12 (IL-12) electrogene therapy has been extensively studied preclinically for cancer treatment.

Purpose of the Study:

To evaluate the antitumor effectiveness of IL-12 electrogene therapy across various preclinical models.
To understand the mechanisms underlying IL-12 electrogene therapy's efficacy.
To assess the potential for clinical translation in oncology.

Main Methods:

Preclinical studies involving different administration routes (intratumoral, intramuscular, peritumoral) and electric pulse protocols.
Testing efficacy against primary tumors, distant tumors, and induced metastases.
Investigating the induction of adaptive immunity, innate resistance, and anti-angiogenic actions.

Main Results:

Intratumoral IL-12 electrogene therapy demonstrated high local tumor control with systemic effects.
Intramuscular and peritumoral administration also showed significant systemic effects.
Combination strategies with IL-12 electrogene therapy led to tumor cures in some models.

Conclusions:

IL-12 electrogene therapy is a potent antitumor strategy with dual local and systemic effects.
The therapy's effectiveness is mediated by immune system activation and anti-angiogenesis.
Clinical trials in human and veterinary oncology are underway, showing encouraging results for further investigation.