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Related Concept Videos

Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Cancer Cell Migration through Invadopodia01:35

Cancer Cell Migration through Invadopodia

Invadosome is a broad category of cell surface structures with proteolytic activity that  degrades the extracellular matrix (ECM). Invadosomes are present in normal cell types, including macrophages, endothelial cells, and neurons, as well as tumor cells. Although the macrophage podosomes and tumor cell invadopodia are classified as invadosomes, they have different structures, molecular pathways, and functions. Podosomes are short structures that last for a few minutes. However, invadopodia can...
Overview of the Vascular System01:20

Overview of the Vascular System

The vascular system comprises an extensive network of arteries, capillaries, and veins. The vascular system can be broadly divided into the blood and lymphatic systems. Typically, blood vessels can be categorized into three histological regions: tunica intima, tunica media, and tunica adventitia. The tunica intima consists of a single layer of endothelial cells attached to the basal lamina. Underlying the basal lamina is a connective tissue layer and an elastic lamina that gives stability and...
Veins of Head and Neck01:19

Veins of Head and Neck

The blood drainage from the head and neck is primarily managed by three pairs of veins: the external jugular, internal jugular, and vertebral veins. The external jugular veins drain superficial scalp and face structures, passing over the sternocleidomastoid muscles to empty into the subclavian veins.
On the other hand, the vertebral veins, unlike their arterial counterparts, are not primarily responsible for brain drainage. Instead, they drain the cervical vertebrae, spinal cord, and some small...
Papillary Dermis01:11

Papillary Dermis

Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen and...

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Related Experiment Video

Updated: Jun 12, 2026

Combining Reflectance Confocal Microscopy with Optical Coherence Tomography for Noninvasive Diagnosis of Skin Cancers via Image Acquisition
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Vascular patterns in basal cell carcinoma.

T Micantonio1, A Gulia, E Altobelli

  • 1Department of Dermatology, University of L'Aquila, L'Aquila, Italy.

Journal of the European Academy of Dermatology and Venereology : JEADV
|June 22, 2010
PubMed
Summary

Arborizing vessels are common in nodular basal cell carcinoma (nBCC), while short fine telangiectasias (SFTs) characterize superficial BCCs (sBCCs). Differentiating other vascular patterns is crucial for accurate diagnosis.

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Area of Science:

  • Dermatology
  • Oncology
  • Medical Imaging

Background:

  • Dermoscopy enhances diagnostic accuracy for basal cell carcinoma (BCC).
  • Understanding BCC vascular patterns aids in differentiating subtypes.

Purpose of the Study:

  • To characterize vascular patterns in superficial and nodular BCC.
  • To determine the frequency of each vascular pattern.

Main Methods:

  • Retrospective analysis of 504 histopathologically proven BCC dermoscopic images.
  • Classification of BCC subtypes into superficial (sBCC) and nodular (nBCC).

Main Results:

  • Arborizing vessels were the most frequent pattern (60.7%), more common in nBCC.
  • Short fine telangiectasias (SFTs) were found in 33.1%, more frequent in sBCC.
  • Other patterns included hairpin, glomerular, dotted, comma, and polymorphous vessels.

Conclusions:

  • Arborizing vessels are characteristic of nBCC.
  • SFTs are characteristic of sBCC.
  • Polymorphous patterns require differential diagnosis with squamous cell carcinoma or melanoma.