Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...
Allergic Reactions02:06

Allergic Reactions

Overview
Asthma-I: Introduction01:29

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Understanding Rurality and Associated Suicide Risks: Perspectives of Adolescents and Caregivers.

Academic pediatrics·2026
Same author

Do financial incentives improve children's long-term adherence to medication in asthma?

Translational pediatrics·2026
Same author

Age-dependent expression and antiviral activity of interferon epsilon in respiratory epithelium.

Journal of virology·2026
Same author

Merging the classical and the modern in physics-based simulations.

Nature computational science·2026
Same author

Approaching rTMS With Openness, Awareness, and Engagement in a Combined Acceptance and Commitment Therapy Framework.

Innovations in clinical neuroscience·2026
Same author

Cognitive functioning in children with both epilepsy and ADHD: A systematic review and meta-analysis.

Brain & development·2026

Related Experiment Video

Updated: Jun 12, 2026

Basophil Activation Test for Allergy Diagnosis
07:22

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

Peanut allergy and allergic airways inflammation.

Jennifer L Hughes1, Trevor Brown, J David Edgar

  • 1Department of Child Health, Clinical Institute, Queen's University of Belfast, Belfast, UK.

Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology
|June 22, 2010
PubMed
Summary

Children with peanut allergy who outgrow asthma may still have airway inflammation. Fractional exhaled nitric oxide (FeNO) levels indicate ongoing eosinophilic inflammation in these children, suggesting continued monitoring may be necessary.

More Related Videos

Antigenic Liposomes for Generation of Disease-specific Antibodies
10:31

Antigenic Liposomes for Generation of Disease-specific Antibodies

Published on: October 25, 2018

Murine Model of Allergen Induced Asthma
08:05

Murine Model of Allergen Induced Asthma

Published on: May 14, 2012

Related Experiment Videos

Last Updated: Jun 12, 2026

Basophil Activation Test for Allergy Diagnosis
07:22

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

Antigenic Liposomes for Generation of Disease-specific Antibodies
10:31

Antigenic Liposomes for Generation of Disease-specific Antibodies

Published on: October 25, 2018

Murine Model of Allergen Induced Asthma
08:05

Murine Model of Allergen Induced Asthma

Published on: May 14, 2012

Area of Science:

  • Pediatric Allergy and Immunology
  • Respiratory Medicine
  • Clinical Investigation

Background:

  • Asthma is a significant risk factor for fatal anaphylaxis in children with peanut allergy.
  • While some children outgrow asthma, ongoing eosinophilic airway inflammation may persist.
  • The necessity of inhaled corticosteroid treatment in peanut-allergic children who have outgrown asthma remains unclear.

Purpose of the Study:

  • To measure fractional exhaled nitric oxide (FeNO) levels in peanut-allergic children.
  • To determine if children who have outgrown asthma exhibit elevated FeNO levels, indicating eosinophilic airway inflammation.

Main Methods:

  • Recruited 101 peanut-allergic children aged 4-15 years from pediatric allergy clinics.
  • Measured fractional exhaled nitric oxide (FeNO) using the Niox Mino device.
  • Categorized children into groups: never wheezed, current treated asthma, wheeze no treatment, and outgrown asthma.

Main Results:

  • All 7 children who had outgrown asthma showed elevated FeNO levels (> 35 ppb).
  • 75% of children with 'wheeze no treatment' also had elevated FeNO levels.
  • Children who outgrew asthma or had 'wheeze no treatment' had significantly higher FeNO than those with no wheeze or current treated asthma (p = 0.003).

Conclusions:

  • Peanut-allergic children who have outgrown asthma demonstrate elevated FeNO levels.
  • Elevated FeNO suggests persistent eosinophilic airway inflammation in children with outgrown asthma.
  • Further investigation into the management of these children is warranted.