Related Experiment Video

Updated: Jun 12, 2026

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay
13:08

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay

Published on: September 9, 2012

[Correlation of inflammatory marker and coagulation factors with deep vein thrombosis]

Mei-Fang Wang1, Lin-Hua Yang, Xiao-Ling Yang

  • 1Department of Hematology, The Second Hospital, Shanxi Medical University, Taiyuan 030001, Shanxi Province, China.

Zhongguo Shi Yan Xue Ye Xue Za Zhi
|June 22, 2010
PubMed

Insights

Deep vein thrombosis (DVT) is closely linked to inflammation and coagulation. Elevated levels of C-reactive protein (CRP), fibrinogen (Fg), and coagulation factors VIII (FVIII:C) and IX (FIX:C) are significant risk factors for DVT.

Area of Science:

  • Biochemistry
  • Hematology
  • Immunology

Context:

  • Deep vein thrombosis (DVT) is a significant health concern.
  • The interplay between inflammation and coagulation in DVT pathogenesis requires further elucidation.

Purpose:

  • To investigate the correlation between deep vein thrombosis (DVT) and key inflammatory and coagulation markers.
  • To explore the role of inflammation and coagulation interactions in the mechanism of DVT.

Summary:

  • This study compared plasma levels of C-reactive protein (CRP), fibrinogen (Fg), coagulation factor VIII (FVIII:C), and coagulation factor IX (FIX:C) in 59 DVT patients and 26 controls.
  • Significantly higher levels of CRP, Fg, FVIII:C, and FIX:C were observed in the DVT group (p < 0.01).
  • Plasma CRP levels strongly correlated with Fg, FVIII:C, and FIX:C (p < 0.01), suggesting a link between inflammation and coagulation.

Impact:

  • Elevated plasma CRP may serve as a predictor for DVT.
  • Increased plasma levels of Fg, FVIII:C, and FIX:C are identified as crucial risk factors for DVT.
  • The interaction between inflammation and coagulation pathways is implicated as a significant factor in DVT development.

More Related Videos

A Multicenter MRI Protocol for the Evaluation and Quantification of Deep Vein Thrombosis10:26

A Multicenter MRI Protocol for the Evaluation and Quantification of Deep Vein Thrombosis

Published on: June 2, 2015

Related Concept Videos

Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies01:20

Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies

The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
Venous Thrombosis I: Introduction01:30

Venous Thrombosis I: Introduction

Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
Venous Thrombosis III: Interprofessional Care01:29

Venous Thrombosis III: Interprofessional Care

Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
Venous Thrombosis IV: Nursing Management01:30

Venous Thrombosis IV: Nursing Management

Nursing management begins with a thorough assessment of the patient's health history. Key factors include trauma to veins, peripherally inserted central catheters, varicose veins, recent pregnancy or childbirth, surgery, bacteremia, prolonged bed rest, atrial fibrillation, COPD, heart failure, cancer, coagulation disorders, myocardial infarction, spinal cord injury, stroke, prolonged travel, recent bone fractures, and dehydration. Review medication intake, particularly oral contraceptives,...
Extrinsic and Intrinsic Pathways of Hemostasis01:20

Extrinsic and Intrinsic Pathways of Hemostasis

Blood clotting or coagulation involves extrinsic and intrinsic pathways, which ultimately merge into the common pathway, forming a fibrin clot.
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which forms a...