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Updated: Jun 12, 2026

Genetic Analysis of Hereditary Transthyretin Ala97Ser Related Amyloidosis
Published on: June 9, 2018
[Pleural amyloidosis attesting to generalised amyloidosis]
C Aichaouia1, M R Ben Meftah, S M'hamdi
1Service de pneumologie-allergologie , hôpital militaire principal d'instruction de Tunis, 1008 Tunis, Tunisie. chirazaichaouia@yahoo.fr
Abstract:
During the course of generalised amyloidosis, pulmonary diseases are mainly represented by tracheobronchial involvement and diffuse or nodular parenchymal localizations. The authors report the case of a 61-year-old woman presenting exudative pleural effusion. The diagnosis of generalised amyloidosis in association with multiple myeloma with cardiac and renal involvement was established. A thoracoscopy performed during the investigation of the pleural effusion and the biopsy revealed amyloid deposits in the pleura. The patient died although melphalan/prednisone treatment was initiated. Pleural involvement in amyloidosis is without doubt under-estimated and plays a central role in the creation and persistence of pleural effusion.
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