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Hypolipidemic and antioxidant effects of mulberry (Morus alba L.) fruit in hyperlipidaemia rats
Xiaolan Yang1, Lei Yang, Haiying Zheng
1School of Life Science and Technology, Shanxi University, No 92, Wucheng Road, Taiyuan 030006, Shanxi Province, PR China. 471914153@qq.com
Abstract:
The phytochemical constituents of a freeze-dried powder of mulberry (Morus alba L.) fruit (MFP) were determined. The hypolipidemic and antioxidant effects of the MFP as a dietary supplement were evaluated in rats who were fed 4 weeks of either a high-fat or a normal diet supplemented with 5% or 10% MFP. Administration of MFP to rats on a high-fat diet resulted in a significant decline in levels of serum and liver triglyceride, total cholesterol, serum low-density lipoprotein cholesterol, and a decrease in the atherogenic index, while the serum high-density lipoprotein cholesterol was significantly increased. In addition, the serum and liver content of thiobarbituric acid related substances, a lipid peroxidation product, significantly decreased, while the superoxide dismutase (SOD) of red blood cell and liver, as well blood glutathione peroxidase (GSH-Px) activities significantly increased. No significant changes in lipid profile in the serum and liver were observed in rats on a normal diet supplemented with MFP, but blood and liver antioxidant status improved, as measured by SOD and GSH-Px activity, and lipid peroxidation was reduced. These beneficial effects of MFP on hyperlipidaemia rats might be attributed to its dietary fiber, fatty acids, phenolics, flavonoids, anthocyanins, vitamins and trace elements content.
Insights
Mulberry fruit powder (MFP) effectively lowered harmful cholesterol and improved antioxidant status in rats fed a high-fat diet. These findings suggest MFP
Area of Science:
- Nutritional Science
- Pharmacology
- Biochemistry
Background:
- Hyperlipidemia and oxidative stress are significant health concerns.
- Dietary interventions are explored for managing lipid profiles and enhancing antioxidant defense.
- Mulberry (Morus alba L.) fruit is recognized for its rich phytochemical composition.
Purpose of the Study:
- To investigate the hypolipidemic and antioxidant effects of mulberry fruit powder (MFP).
- To evaluate MFP as a dietary supplement in a rat model.
- To determine the impact of MFP on lipid profiles and oxidative stress markers.
Main Methods:
- Freeze-dried mulberry fruit powder (MFP) was prepared.
- Rats were fed a high-fat or normal diet supplemented with 5% or 10% MFP for 4 weeks.
- Serum and liver lipid profiles, lipid peroxidation products, and antioxidant enzyme activities (superoxide dismutase and glutathione peroxidase) were measured.
Main Results:
- MFP administration significantly reduced serum and liver triglyceride, total cholesterol, and LDL cholesterol in high-fat diet rats.
- MFP increased HDL cholesterol and decreased the atherogenic index in hyperlipidemic rats.
- MFP supplementation improved antioxidant status by decreasing lipid peroxidation and increasing SOD and GSH-Px activities in both normal and high-fat diet groups.
Conclusions:
- Mulberry fruit powder (MFP) demonstrates significant hypolipidemic and antioxidant properties.
- MFP may be a beneficial dietary supplement for managing hyperlipidemia and oxidative stress.
- The observed effects are likely due to the rich content of dietary fiber, fatty acids, phenolics, flavonoids, anthocyanins, vitamins, and trace elements in MFP.
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