Related Experiment Video
Updated: Jun 12, 2026

Lipid Vesicle-mediated Affinity Chromatography using Magnetic Activated Cell Sorting (LIMACS): a Novel Method to Analyze Protein-lipid Interaction
Published on: April 26, 2011
Resorcinolic lipids improve the properties of sphingomyelin-cholesterol liposomes
E Zant-Przeworska1, M Stasiuk, J Gubernator
1Faculty of Biotechnology, Department of Lipids and Liposomes, University of Wroclaw, Przybyszewskiego 63/77, 51-148 Wroclaw, Poland.
Abstract:
Alkylresorcinolic lipids isolated from cereal grains and their semi-synthetic myristoyl-sulphonyl derivatives (MSAR) were used to modify small long-circulating sphingomyelin-cholesterol liposomes. Those SM:Chol vesicles modified with 10-30 mol% resorcinolic lipids had stable size and low membrane permeability in vitro at 4 degrees C and 37 degrees C. Liposomes containing 30 mol% MSAR showed very fast solute release in the presence of human plasma at 37 degrees C, which was drastically diminished in heat-inactivated plasma. In vivo studies showed that unmodified SM:Chol liposomes and those modified with alkylresorcinols were eliminated from the circulation more slowly than liposomes with the highest concentration of MSAR in membrane and were located mostly in the liver and spleen.
Related Concept Videos
Assembly of the Lipid Bilayer in the ER
A large chunk of any biological membrane is composed of phospholipids. These lipids have a heterogeneous distribution across different subcellular organelles and even between...
Asymmetric Lipid Bilayer
Biosynthesis of Lipids
Membrane Lipids
Phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, and sphingomyelin are the most common phospholipids present in mammalian membranes. At physiological pH, phosphatidylserine is negatively charged, while the other three...
Membrane Lipids
Phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, and sphingomyelin are the most common phospholipids present in mammalian membranes. At physiological pH, phosphatidylserine is negatively charged, while the other three...
Lipids as Anchors
The carboxy-terminal of most of the prenylated proteins, such as Ras proteins, contains the...

