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A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats

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White matter hyperintensities in post-stroke depression: a case control study.

W K Tang¹, Y K Chen, J Y Lu

¹Department of Psychiatry, Chinese University of Hong Kong, Hong Kong SAR, China. tangwk@cuhk.edu.hk

Journal of Neurology, Neurosurgery, and Psychiatry

|June 22, 2010

Summary

This summary is machine-generated.

Severe deep white matter hyperintensities (WMHs) are linked to post-stroke depression (PSD) in Chinese patients. This finding suggests WMHs may contribute to PSD development, warranting further research into their role in treatment and outcomes.

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Published on: January 9, 2026

Area of Science:

Neurology
Psychiatry
Radiology

Background:

Post-stroke depression (PSD) is a common complication following stroke.
The exact mechanisms underlying PSD are not fully understood.
The contribution of white matter hyperintensities (WMHs) to PSD pathogenesis requires clarification.

Purpose of the Study:

To investigate the association between white matter hyperintensities (WMHs) and post-stroke depression (PSD).
To evaluate WMHs in Chinese patients experiencing their first or recurrent stroke.

Main Methods:

A cohort of 994 acute ischemic stroke patients was recruited.
Post-stroke depression (PSD) was diagnosed using the Structural Clinical Interview for DSM-IV 3 months post-stroke.
Magnetic resonance imaging (MRI) assessed the severity and location of white matter hyperintensities (WMHs).

Main Results:

Patients with PSD were significantly more likely to have severe deep WMHs compared to the non-PSD group (12.8% vs 1.3%, p=0.009).
Severe deep WMHs were identified as an independent predictor of PSD (OR=13.8, p=0.016).

Conclusions:

White matter hyperintensities (WMHs) appear to play a role in the development of post-stroke depression (PSD).
Further investigation is needed to understand the significance of WMHs in PSD treatment and prognosis.