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Updated: Feb 6, 2026

LINE-1 Methylation Analysis in Mesenchymal Stem Cells Treated with Osteosarcoma-Derived Extracellular Vesicles
Published on: February 1, 2020
Moyamoya in a child treated with interferon for recurrent osteosarcoma
David Buchbinder1, Gary Steinberg, Michael Linetsky
1Division of Hematology, Department of Pediatrics, Children's Hospital of Orange County, Main Street, Orange, USA. dbuchbinder@choc.org
Summary:
Moyamoya is a cerebral vasculopathy of unknown etiology rarely described as a late effect after the treatment of childhood cancer. We describe a 12-year-old female who developed moyamoya after the completion of systemic chemotherapy, surgery, and adjuvant interferon alpha for osteosarcoma with pulmonary metastases. Given the importance of characterizing late effects after the treatment of childhood cancer, the potential role of interferon alpha in the development of moyamoya is discussed.
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