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Updated: Jun 12, 2026

Spatiotemporal Control of Protein Activity through Optogenetic Allosteric Regulation
Published on: October 4, 2024
Rationally improving LOV domain-based photoswitches
Devin Strickland1, Xiaolan Yao, Grzegorz Gawlak
1Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, Illinois, USA.
Abstract:
Genetically encoded protein photosensors are promising tools for engineering optical control of cellular behavior; we are only beginning to understand how to couple these light detectors to effectors of choice. Here we report a method that increases the dynamic range of an artificial photoswitch based on the LOV2 domain of Avena sativa phototropin 1 (AsLOV2). This approach can potentially be used to improve many AsLOV2-based photoswitches.
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