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Ral activation promotes melanomagenesis

P A Zipfel1, D C Brady, D F Kashatus

  • 1Department of Surgery, Duke University Medical Center, Durham, NC, USA.

Oncogene
|June 22, 2010
PubMed
Summary

Small guanosine triphosphatase (GTPase) Ral proteins are activated in melanoma, regardless of NRAS or BRAF mutation status. Inhibiting RalA and RalB with short hairpin RNA (shRNA) reduced melanoma cell growth, indicating Rals promote tumorigenesis.

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