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Metabolic profile and cardiovascular risk factors among Latin American HIV-infected patients receiving HAART

P Cahn1, O Leite, A Rosales

  • 1Huésped Foundation, Buenos Aires, Argentina.

The Brazilian Journal of Infectious Diseases : an Official Publication of the Brazilian Society of Infectious Diseases
|June 22, 2010
PubMed

Insights

Metabolic abnormalities and cardiovascular disease (CVD) risk are high in Latin American patients on highly active anti-retroviral therapy (HAART). Longer HAART duration correlates with increased CVD risk, necessitating interventions.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Metabolic Disorders

Background:

  • Highly active anti-retroviral therapy (HAART) has transformed HIV management but may be associated with metabolic abnormalities (MA).
  • Cardiovascular disease (CVD) is a significant concern for HIV-infected individuals, particularly those on long-term HAART.
  • Latin American populations may have unique risk factor profiles for MA and CVD.

Purpose of the Study:

  • To determine the prevalence of metabolic abnormalities (MA).
  • To estimate the 10-year cardiovascular disease (CVD) risk.
  • To analyze these factors in Latin American patients receiving highly active anti-retroviral therapy (HAART).

Main Methods:

  • A cohort study was conducted across seven Latin American countries.
  • Adult HIV-infected patients with at least one month of HAART were enrolled.
  • Baseline data on metabolic parameters and CVD risk factors were collected.

Main Results:

  • Prevalence of dyslipidemia was 80.2% and metabolic syndrome was 20.2% in 4,010 patients.
  • The mean 10-year CVD risk (Framingham Risk Score) was 10.4%.
  • Longer HAART duration was linked to higher prevalence of MA and increased CVD risk, particularly in males.

Conclusions:

  • Traditional CVD risk factors are common in this population, contributing to intermediate CVD risk.
  • Intervention and education programs targeting risk factor modification are crucial for reducing CVD burden.
  • Further research into optimizing HAART regimens and managing metabolic complications is warranted.
Abstract

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