Systemic inflammation caused by chronic periodontite in patients victims of acute ischemic heart attack

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Updated: Jun 12, 2026

A Mouse Model for Pathogen-induced Chronic Inflammation at Local and Systemic Sites
09:52

A Mouse Model for Pathogen-induced Chronic Inflammation at Local and Systemic Sites

Published on: August 8, 2014

Fernando José de Oliveira1, Reinaldo Wilson Vieira, Otávio Rizzi Coelho

  • 1Pharmacology and Surgery Department at Faculty of Medical Sciences at UNICAMP, Campinas, SP, Brazil. fernandoimplantes@hotmail.com

Revista Brasileira De Cirurgia Cardiovascular : Orgao Oficial Da Sociedade Brasileira De Cirurgia Cardiovascular
|June 22, 2010
PubMed

Insights

Severe chronic periodontitis is linked to altered lipid profiles and the presence of periodontal bacteria in coronary arteries of patients with acute ischemic heart disease (AIHD). This highlights a potential oral-cardiac connection.

Area of Science:

  • Cardiology
  • Periodontology
  • Infectious Diseases

Background:

  • Infectious and inflammatory processes from distant sites are recognized risk factors for acute ischemic heart disease (AIHD).
  • The potential role of chronic periodontitis (CP) in the pathogenesis of AIHD requires further investigation.

Purpose of the Study:

  • To investigate the association between chronic periodontitis and acute ischemic heart disease.
  • To analyze lipid profiles, hematological parameters, and blood glucose levels in AIHD patients with varying severity of CP.
  • To detect the presence of periodontal bacteria in coronary artery tissues of AIHD patients.

Main Methods:

  • A cohort of 101 AIHD patients was stratified into three groups based on CP severity: severe CP, mild CP, and edentulous.
  • Blood samples were analyzed for lipid profiles, hematological parameters, and blood glucose.
  • Coronary artery biopsies from patients with severe CP were examined for the presence of atherosclerotic degeneration and periodontal bacteria DNA.

Main Results:

  • Patients with severe CP exhibited elevated triglyceride and LDL levels, and reduced HDL levels compared to those with mild CP.
  • Higher blood glucose levels were observed in the severe CP group.
  • Periodontal bacteria DNA was detected in 58.8% of coronary artery samples from patients with severe CP.

Conclusions:

  • Severe chronic periodontitis is associated with dyslipidemia and hyperglycemia in AIHD patients.
  • Periodontal bacteria can translocate to coronary vessels, suggesting a potential mechanism linking CP to AIHD.
Abstract

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