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Published on: January 7, 2019
Multiple lymphomatous polyposis overexpressing cyclin D1.
H Tsujimura1, T Takagi, J Tamaru
1Division of Hematology-Oncology, Chiba Cancer Center Hospital, 666-2 Nitona-cho, Chuo-ku, Chiba 260-8717, Japan Tel. +81-43-264-5431; Fax +81-43-265-9515 e-mail: htsujimu-cib@umin.ac.jp, , , , , , JP.
International Journal of Clinical Oncology
|June 22, 2010
Summary
This case report details a rare instance of mantle cell lymphoma (MCL) with multiple lymphomatous polyposis (MLP) in the gastrointestinal tract. An irinotecan-adriamycin regimen achieved good partial remission, maintaining patient wellness for 48 months.
Area of Science:
- Oncology
- Gastroenterology
- Hematology
Background:
- Mantle cell lymphoma (MCL) is a rare non-Hodgkin lymphoma.
- Multiple lymphomatous polyposis (MLP) is an uncommon manifestation of lymphoma in the gastrointestinal tract.
- The association between MCL and MLP presents unique diagnostic and therapeutic challenges.
Purpose of the Study:
- To report a case of mantle cell lymphoma (MCL) associated with multiple lymphomatous polyposis (MLP).
- To describe the clinical features, diagnostic findings, and treatment response in this specific patient.
- To highlight the management of a rare gastrointestinal manifestation of MCL.
Main Methods:
- Clinical case presentation and review.
- Diagnostic procedures including immunohistochemical examination of polypoid lesions.
- Treatment regimen administration and response monitoring.
Main Results:
- A 62-year-old woman presented with widespread polypoid lesions throughout the gastrointestinal tract, diagnosed as MCL with MLP.
- Neoplastic cells stained positive for cyclin D1.
- Conventional chemotherapy regimens (CHOP, MEVP) showed limited efficacy.
- An irinotecan-adriamycin regimen resulted in good partial remission, with the patient remaining well for 48 months.
Conclusions:
- Mantle cell lymphoma can present as multiple lymphomatous polyposis in the gastrointestinal tract.
- Treatment with an irinotecan-adriamycin regimen can be effective in achieving durable remission for this rare presentation.
- This case underscores the importance of considering rare lymphoma manifestations and individualized treatment approaches.
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