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Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...
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Multiple lymphomatous polyposis overexpressing cyclin D1.

H Tsujimura1, T Takagi, J Tamaru

  • 1Division of Hematology-Oncology, Chiba Cancer Center Hospital, 666-2 Nitona-cho, Chuo-ku, Chiba 260-8717, Japan Tel. +81-43-264-5431; Fax +81-43-265-9515 e-mail: htsujimu-cib@umin.ac.jp, , , , , , JP.

International Journal of Clinical Oncology
|June 22, 2010
PubMed
Summary

This case report details a rare instance of mantle cell lymphoma (MCL) with multiple lymphomatous polyposis (MLP) in the gastrointestinal tract. An irinotecan-adriamycin regimen achieved good partial remission, maintaining patient wellness for 48 months.

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Area of Science:

  • Oncology
  • Gastroenterology
  • Hematology

Background:

  • Mantle cell lymphoma (MCL) is a rare non-Hodgkin lymphoma.
  • Multiple lymphomatous polyposis (MLP) is an uncommon manifestation of lymphoma in the gastrointestinal tract.
  • The association between MCL and MLP presents unique diagnostic and therapeutic challenges.

Purpose of the Study:

  • To report a case of mantle cell lymphoma (MCL) associated with multiple lymphomatous polyposis (MLP).
  • To describe the clinical features, diagnostic findings, and treatment response in this specific patient.
  • To highlight the management of a rare gastrointestinal manifestation of MCL.

Main Methods:

  • Clinical case presentation and review.
  • Diagnostic procedures including immunohistochemical examination of polypoid lesions.
  • Treatment regimen administration and response monitoring.

Main Results:

  • A 62-year-old woman presented with widespread polypoid lesions throughout the gastrointestinal tract, diagnosed as MCL with MLP.
  • Neoplastic cells stained positive for cyclin D1.
  • Conventional chemotherapy regimens (CHOP, MEVP) showed limited efficacy.
  • An irinotecan-adriamycin regimen resulted in good partial remission, with the patient remaining well for 48 months.

Conclusions:

  • Mantle cell lymphoma can present as multiple lymphomatous polyposis in the gastrointestinal tract.
  • Treatment with an irinotecan-adriamycin regimen can be effective in achieving durable remission for this rare presentation.
  • This case underscores the importance of considering rare lymphoma manifestations and individualized treatment approaches.