Related Experiment Video

Updated: Jun 12, 2026

Methyl-binding DNA capture Sequencing for Patient Tissues
08:40

Methyl-binding DNA capture Sequencing for Patient Tissues

Published on: October 31, 2016

Expression and methylation status of the Syk gene in cervical carcinoma

Shuping Zhao1, Guixia Sun, Parks W Tony

  • 1Department of Gynecology, Affiliated Hospital of Medical College of Qingdao University, Qingdao 266003, China. shuping.zhao@yahoo.com

Archives of Gynecology and Obstetrics
|June 22, 2010
PubMed
Abstract

Insights

Spleen tyrosine kinase (Syk) loss is linked to cervical cancer development. Reduced Syk expression was observed in cervical precancerous lesions and cancer, suggesting its role in disease progression.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Spleen tyrosine kinase (Syk) is a non-receptor protein tyrosine kinase.
  • Syk acts as a tumor suppressor, with decreased expression linked to malignancy and poor prognosis in various cancers.

Purpose of the Study:

  • To investigate the role of Syk in cervical cancer.
  • To determine the precise function of Syk in the development of cervical cancer.

Main Methods:

  • Methylation-specific PCR (MSP) and RT-PCR were used.
  • Analysis of Syk methylation status and mRNA expression in normal, CIN, and cervical cancer tissues.

Main Results:

  • Syk expression was present in all normal cervical tissues and CIN1 samples.
  • Syk expression was detected in 56% of CIN2/3 samples, indicating a decrease in higher-grade lesions.

Conclusions:

  • Loss of Syk expression is potentially associated with cervical carcinogenesis.
  • Syk may function as a tumor suppressor in cervical cancer development.

More Related Videos

Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer07:50

Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer

Published on: September 18, 2020

Related Concept Videos

Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic cells are...
Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
The JAK-STAT Signaling Pathway01:20

The JAK-STAT Signaling Pathway

Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as  SH2...