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Updated: Jun 12, 2026

Isolation and Culture of Adult Epithelial Stem Cells from Human Skin
Published on: March 31, 2011
Epithelial stem cells: an epigenetic and Wnt-centric perspective
Bingnan Gu1, Kazuhide Watanabe, Xing Dai
1Department of Biological Chemistry, School of Medicine, University of California, Irvine, California 92697-1700, USA.
Abstract:
Epithelial stem cells, such as those present in mammalian skin, intestine, or mammary gland, are tissue stem cells capable of both long-term self-renewal and multi-lineage differentiation. Here we review studies implicating epigenetic control mechanisms in mammalian epithelial stem cell development and homeostasis. We also provide an update of recent progresses in the involvement of canonical Wnt signaling and note an interesting link between the Wnt pathway and chromatin regulation in epithelial stem cells. We anticipate that epigenetic and epigenomic studies of these cells will increase exponentially in the near future.
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