Specific grasp characteristics of children with trisomy 21

Marianne Jover1, Catherine Ayoun, Catherine Berton

  • 1Département de Psychologie Développementale et Différentielle, Centre PsyCLE, Université Aix Marseille 1, 29 Avenue Robert Schuman, Aix en Provence Cedex 1, France. marianne.jover@univ-provence.fr

Insights

Children with trisomy 21 exhibit distinct manual skills, using fewer fingers and unique grasps. These atypical traits persist throughout development, indicating a unique developmental trajectory.

Area of Science:

  • Developmental Psychology
  • Pediatrics
  • Genetics

Background:

  • Children with trisomy 21 (Down syndrome) often show differences in motor skills.
  • Understanding manual skill development in this population is crucial for targeted interventions.

Purpose of the Study:

  • To investigate the grasp characteristics and their developmental changes in children with trisomy 21.
  • To compare manual skills of children with trisomy 21 to typically developing peers.

Main Methods:

  • Assessed grasp patterns in 35 children with trisomy 21 (aged 4-18) during standardized manual tasks.
  • Included grasping wooden blocks of varying sizes and tasks from the Movement Assessment Battery for Children.
  • Compared findings with 35 age-matched typically developing children.

Main Results:

  • Children with trisomy 21 consistently used fewer fingers across tasks.
  • They exhibited specific grasp patterns, including extending non-engaged fingers.
  • Some atypical grasp features diminished with age, while others remained consistent.

Conclusions:

  • Manual skills in children with trisomy 21 represent an atypical developmental pattern, not merely a delay.
  • These findings highlight the need to consider unique developmental trajectories in trisomy 21.
  • Further research into perceptual-motor development in trisomy 21 is warranted.

Related Concept Videos

Meiosis I01:49

Meiosis I

Meiosis is a carefully orchestrated set of cell divisions, the goal of which—in humans—is to produce haploid sperm or eggs, each containing half the number of chromosomes present in somatic cells elsewhere in the body. Meiosis I is the first such division, and involves several key steps, among them: condensation of replicated chromosomes in diploid cells; the pairing of homologous chromosomes and their exchange of information; and finally, the separation of homologous chromosomes by a...
Karyotyping01:17

Karyotyping

Describing the number and physical features of chromosomes can reveal abnormalities that underlie genetic diseases. This description is facilitated by special staining techniques that produce a particular banding pattern on each chromosome. State-of-the-art techniques make this approach even more powerful, enabling the detection of individual genes that cause disease.A Simple Chromosome Staining Technique Provides Valuable Scientific InsightSome genetic diseases can be detected by looking at...
Nondisjunction01:21

Nondisjunction

Nondisjunction is the failure of homologous chromosomes or sister chromatids to separate correctly and move to the opposite poles of the cells. This produces daughter cells with abnormal chromosome numbers.  Nondisjunction is common during anaphase I or anaphase II of meiosis.  Mutations in synaptonemal complex proteins that attach homologous chromosomes increase the chances of nondisjunction in anaphase I of meiosis I. In contrast, mutations in topoisomerases and condensins that hold sister...
Nondisjunction01:29

Nondisjunction

During meiosis, chromosomes occasionally separate improperly. This occurs due to failure of homologous chromosome separation during meiosis I or failed sister chromatid separation during meiosis II. In some species, notably plants, nondisjunction can result in an organism with an entire additional set of chromosomes, which is called polyploidy. In humans, nondisjunction can occur during male or female gametogenesis and the resulting gametes possess one too many or one too few chromosomes.