Related Experiment Video
Updated: Jun 12, 2026
06:16
Preparation Of Gushukang (GSK) Granules for In Vivo and In Vitro Experiments
Published on: May 9, 2019
Systemic effect of Fructus Psoraleae extract on bone in mice
Ricky W K Wong1, A Bakr M Rabie
1Biomedical and Tissue Engineering Research Group, University of Hong Kong, Prince Philip Dental Hospital, 34 Hospital Road, Sai Ying Pun, Hong Kong. fyoung@hkucc.hku.hk
Phytotherapy Research : PTR
|June 22, 2010
Summary
Fructus Psoraleae extract consumption significantly enhanced bone density and altered bone structure in mice. This traditional Chinese medicine shows promise for treating bone diseases by improving bone volume and trabeculae thickness.
Area of Science:
- Bone biology and histomorphology
- Pharmacology of traditional Chinese medicine
- Preclinical research in osteoporosis models
Background:
- Fructus Psoraleae (Psoralea corylifolia) is a traditional Chinese herb used for bone disease treatment.
- Understanding the systemic effects of Fructus Psoraleae extract on bone is crucial for its therapeutic application.
Purpose of the Study:
- To investigate the systemic effects of oral Fructus Psoraleae extract consumption on bone histomorphology in a mouse model.
- To quantify changes in bone structure parameters following Fructus Psoraleae extract administration.
Main Methods:
- A controlled study involving 16 male BALB/c mice, divided into control and Fructus Psoraleae extract-treated groups.
- Oral administration of Fructus Psoraleae extract or distilled water for 5 weeks.
- High-resolution micro-computed tomography (micro-CT) analysis of proximal tibia for quantitative morphometry.
Main Results:
- Fructus Psoraleae extract consumption significantly increased the bone volume/tissue volume ratio by 11.8%.
- Bone trabeculae thickness increased by 7.1%, indicating enhanced bone density.
- Significant alterations in bone histomorphology were observed in the experimental group.
Conclusions:
- Oral administration of Fructus Psoraleae extract demonstrably increases bone density.
- Fructus Psoraleae extract alters bone histomorphology, suggesting a potential therapeutic role in bone diseases.
- This study provides quantitative evidence for the bone-enhancing effects of Fructus Psoraleae extract.