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Related Concept Videos

Magnetic Resonance Imaging01:24

Magnetic Resonance Imaging

Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...

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Quantitative Magnetic Resonance Imaging of Skeletal Muscle Disease
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T1 corrected B1 mapping using multi-TR gradient echo sequences.

Tobias Voigt1, Kay Nehrke, Olaf Doessel

  • 1Institute of Biomedical Engineering, University of Karlsruhe, Karlsruhe, Germany. tobias.voigt@kit.edu

Magnetic Resonance in Medicine
|June 22, 2010
PubMed
Summary
This summary is machine-generated.

A new multiple TR B(1)/T(1) mapping (MTM) technique offers faster, simultaneous radiofrequency field and T(1) measurements. MTM improves accuracy and signal-to-noise ratio compared to standard actual flip angle imaging (AFI).

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Area of Science:

  • Magnetic Resonance Imaging
  • Quantitative MRI
  • Biomedical Engineering

Background:

  • Accurate radiofrequency field (B(1)) and T(1) mapping are crucial for quantitative MRI.
  • Standard actual flip angle imaging (AFI) provides simultaneous B(1)/T(1) mapping but can be limited by accuracy and signal-to-noise ratio.
  • There is a need for improved techniques for fast and reliable B(1) and T(1) quantification.

Purpose of the Study:

  • To introduce and validate a novel "multiple TR B(1)/T(1) mapping" (MTM) technique.
  • To compare the performance of MTM against the standard AFI sequence.
  • To assess the feasibility, reliability, and accuracy of MTM for B(1) and T(1) quantification.

Main Methods:

  • Developed the MTM technique by modifying the standard AFI sequence with multiple pulse repetition time (TR) sets.
  • Conducted simulations and phantom experiments to investigate MTM's performance.
  • Performed in vivo experiments to evaluate MTM's feasibility and reliability in biological tissues.
  • Applied error propagation theory for parameter optimization and noise analysis.

Main Results:

  • MTM demonstrated feasibility and reliability in both phantom and in vivo experiments.
  • Simulations and experiments showed MTM outperforms standard AFI in accuracy and signal-to-noise ratio across various T(1) values.
  • Error propagation analysis provided insights into optimal sequence parameters and noise characteristics.
  • Qualitative and quantitative analysis confirmed MTM's T(1) determination capability, showing good agreement with reference measurements.

Conclusions:

  • The multiple TR B(1)/T(1) mapping (MTM) technique is a viable advancement for simultaneous B(1) and T(1) quantification.
  • MTM offers superior accuracy and signal-to-noise ratio compared to standard AFI, enhancing quantitative MRI applications.
  • This method holds promise for improving the speed and reliability of MRI-based tissue parameter measurements.