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Published on: November 25, 2017

Parameters quantifying dehydration in canine vocal fold lamina propria.

Kevin P Hanson1, Yu Zhang, Jack J Jiang

  • 1Department of Surgery, Division of Otolaryngology-Head and Neck Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.

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|June 22, 2010
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Summary

This study measured canine vocal fold lamina propria tissue properties at different dehydration levels. Results support the biphasic theory, suggesting dehydration can quantify vocal fold tissue biomechanics.

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Area of Science:

  • Biomedical Engineering
  • Physiology
  • Acoustic Science

Background:

  • The biphasic theory of vocal fold physiology and biomechanics posits that vocal folds behave as a two-component system.
  • Understanding tissue properties under varying hydration is crucial for validating this theory.

Purpose of the Study:

  • To quantify solid and liquid components of canine vocal fold lamina propria tissue.
  • To assess tissue properties at different dehydration levels (30%, 50%, 70%).
  • To test the biphasic theory using measured parameters.

Main Methods:

  • Dissection of canine vocal fold lamina propria (30 samples from 15 larynges).
  • Measurement of initial mass and volume.
  • Sequential mass measurements during controlled dehydration.
  • Calculation of liquid/solid mass and volume fractions and ratios.

Main Results:

  • Significant differences in liquid mass/volume fractions and liquid:solid ratios were observed across dehydration levels.
  • Linear regression indicated predictable relationships between dehydration level and tissue parameters.
  • Liquid:solid volume ratios showed no significant difference between 30% and 50% dehydration.

Conclusions:

  • Experimental data support the biphasic theory of vocal fold biomechanics.
  • Vocal fold lamina propria tissue dehydration extent can be quantified using biphasic model parameters.