Related Experiment Video

Updated: Jun 12, 2026

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
07:25

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

Published on: March 6, 2018

[New drugs at the horizon for men with prostate cancer]

Keyvan Shabafrouz1, Jean Bauer, Dominik R Berthold

  • 1Centre pluridisciplinaire d'oncologie CHUV, 1011 Lausanne.

Revue Medicale Suisse
|June 23, 2010
PubMed

Insights

New treatments for advanced prostate cancer show promise. These include hormonal therapies, chemotherapy, vaccines, and targeted drugs, offering hope for improved patient outcomes.

Area of Science:

  • Oncology
  • Urology
  • Pharmacology

Context:

  • Metastatic prostate cancer treatment remains challenging despite advances in understanding its biology.
  • Recent randomized controlled trials have yielded promising or positive results for novel therapies.

Purpose:

  • To review emerging treatments for advanced prostate cancer with potential for near-term clinical application.
  • To highlight key therapeutic classes including hormonal agents, chemotherapy, immunotherapy, anti-angiogenic drugs, radiopharmaceuticals, and bone agents.

Summary:

  • Discusses novel hormonal treatments like Abiraterone and MDV3100.
  • Covers new chemotherapy agent Cabazitaxel and cellular vaccine Sipuleucel-T.
  • Includes anti-angiogenic drugs (Bevacizumab, Aflibercept), radioactive treatment Alpharadin, and bone agent Denosumab.

Impact:

  • These emerging therapies may significantly improve clinical management of advanced prostate cancer.
  • Provides clinicians with an overview of future treatment options for improved patient care.
  • Highlights the rapid evolution of therapeutic strategies in metastatic prostate cancer.

More Related Videos

A New Technique for Treating Low-risk Prostate Cancer—Super Active Surveillance05:19

A New Technique for Treating Low-risk Prostate Cancer—Super Active Surveillance

Published on: November 7, 2025

Related Concept Videos

FDA Approved Drugs: Changes to Approved Drugs01:26

FDA Approved Drugs: Changes to Approved Drugs

Post-approval, manufacturers may modify an approved new or generic drug product. Such modifications can encompass alterations in the Active Pharmaceutical Ingredient (API), manufacturing process, formulation, batch size, manufacturing site, and container closure system (FDA Guidance for Industry, April 2004). Often, a drug product may undergo multiple changes.These modifications require careful evaluation to determine their potential impact on the drug product's identity, strength, quality,...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Treatment Resistent Cancers02:56

Treatment Resistent Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...