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Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...
Tissue Transplantation01:24

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...

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Related Experiment Video

Updated: Jun 12, 2026

Porcine Liver Transplantation Without Veno-Venous Bypass As an Extended Criteria Donor Model
12:49

Porcine Liver Transplantation Without Veno-Venous Bypass As an Extended Criteria Donor Model

Published on: August 17, 2022

Liver transplant: a primer.

Zohreh Movahedi1, Curtis D Holt, Sammy Saab

  • 1Department of Gastroenterology, Pancreas Research Group, UCLA/VA Greater Los Angeles Healthcare System, USA.

Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation
|June 23, 2010
PubMed
Summary
This summary is machine-generated.

Liver transplant success has improved due to immunosuppressive drugs. However, these drugs increase risks of infection and other complications, necessitating careful regimen selection for better patient outcomes.

Related Experiment Videos

Last Updated: Jun 12, 2026

Porcine Liver Transplantation Without Veno-Venous Bypass As an Extended Criteria Donor Model
12:49

Porcine Liver Transplantation Without Veno-Venous Bypass As an Extended Criteria Donor Model

Published on: August 17, 2022

Area of Science:

  • Transplantation immunology
  • Pharmacology

Background:

  • Liver transplantation is a successful treatment for end-stage liver disease.
  • Patient and graft survival rates have improved significantly over the last 20 years, largely due to advancements in immunosuppressive therapy.

Purpose of the Study:

  • To review the role and impact of immunosuppressive regimens in liver transplantation.
  • To highlight the benefits and drawbacks of current immunosuppressive strategies.
  • To emphasize the importance of individualized immunosuppression for long-term patient and graft survival.

Main Methods:

  • Review of current literature on immunosuppressive agents used in liver transplantation.
  • Analysis of the mechanisms of action and side effect profiles of various immunosuppressive drug classes.
  • Discussion of the goals and challenges of immunosuppression in solid-organ transplantation.

Main Results:

  • Immunosuppressive regimens, including calcineurin inhibitors, antimetabolites, mTOR inhibitors, steroids, and antibody-based therapies, are crucial for preventing allograft rejection.
  • The non-specific nature of these agents increases the risk of opportunistic infections, renal impairment, metabolic issues, neurotoxicity, de novo malignancies, and disease recurrence.
  • These drugs modulate T-cell activation and B-cell activation, impacting the immune response to the transplanted organ.

Conclusions:

  • Careful selection and management of immunosuppressive regimens are essential for optimizing liver transplant outcomes.
  • Balancing the prevention of rejection with the minimization of adverse effects is critical for improving long-term patient survival and quality of life.
  • Further research into targeted immunosuppression may lead to improved safety and efficacy in liver transplantation.