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09:16
A General Method for Evaluating Deep Brain Stimulation Effects on Intravenous Methamphetamine Self-Administration
Published on: January 22, 2016
Pharmacological approaches to methamphetamine dependence: a focused review
Laurent Karila1, Aviv Weinstein, Henri-Jean Aubin
1Addiction Research and Treatment Center, Paul Brousse Hospital, Paris XI University, AP-HP, CEA- INSERM U1000, Villejuif, France. laurent.karila@pbr.aphp.fr
British Journal of Clinical Pharmacology
|June 23, 2010
Summary
Developing effective medications for methamphetamine dependence remains challenging. While many drugs have failed, modafinil, bupropion, and naltrexone show promise in reducing methamphetamine use.
Area of Science:
- Neuroscience
- Pharmacology
- Public Health
Background:
- Methamphetamine dependence is a global health issue with severe consequences.
- Neuronal mechanisms suggest pharmacological treatment targets.
- Previous research has explored various medication classes.
Purpose of the Study:
- To review the efficacy of medications for treating methamphetamine dependence.
- To identify pharmacological agents that have shown positive results.
Main Methods:
- A comprehensive literature search was conducted across multiple databases (PubMed, EMBASE, PsycInfo, etc.).
- Studies published from January 1985 to October 2009 were included, with no restrictions on publication status, language, or design.
- The review focused on clinical trials evaluating medications for methamphetamine dependence.
Main Results:
- Many medications, including aripiprazole, gabapentin, and SSRIs, failed to demonstrate efficacy.
- Modafinil, bupropion, and naltrexone showed positive results in reducing methamphetamine or amphetamine use in placebo-controlled trials.
- Agonist replacement therapies with d-amphetamine and methylphenidate also showed promise.
Conclusions:
- Most pharmacological interventions for methamphetamine dependence have been unsuccessful to date.
- Modafinil, bupropion, and naltrexone represent promising treatment options.
- Further research and development of novel agents are crucial for effective methamphetamine dependence treatment.
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