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PEGylated inulin as long-circulating pharmaceutical carrier
Guilan Sun1, Xiao Lin, Zhuojun Wang
1College of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, PR China.
This study introduces PEGylated inulin as a novel pharmaceutical carrier, overcoming limitations of traditional options. The new carrier shows promising long circulation times and good absorption for enhanced drug delivery via the EPR effect.
Area of Science:
- Biomaterials Science
- Polymer Chemistry
- Pharmaceutical Sciences
Background:
- Poly(ethylene glycol) and polysaccharides are common pharmaceutical carriers but have drawbacks.
- Limitations necessitate the development of novel drug delivery systems.
Purpose of the Study:
- To prepare and evaluate PEGylated inulin as a novel polymeric carrier.
- To assess the pharmacokinetic properties of PEGylated inulin conjugates.
Main Methods:
- PEGylated inulin conjugates were synthesized by reacting hydroxyl-activated inulin with amino-terminated methoxy-PEGs.
- Pharmacokinetic studies were performed in rats after intravenous (i.v.) and subcutaneous (s.c.) administration.
Main Results:
- PEGylated inulin conjugates exhibited multi-compartmental pharmacokinetics upon i.v. administration.
- Subcutaneous administration showed good absorption (66-79% bioavailability) and prolonged mean retention times (35-179 h).
Conclusions:
- PEGylated inulin demonstrates potential as a pharmaceutical carrier due to its small size and extended circulation.
- The enhanced permeability and retention (EPR) effect suggests utility for targeted drug delivery.
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