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Updated: May 28, 2026

Procedure for Fabricating Biofunctional Nanofibers
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Published on: September 10, 2012

Functionalized poly(L-lactide) nanoparticles from electrospun nanofibers.

Zhiwei Xie1, Gisela Buschle-Diller

  • 1a Department of Polymer and Fiber Engineering, Auburn University, Auburn, AL 36849-5327, USA.

Journal of Biomaterials Science. Polymer Edition
|June 23, 2010
PubMed
Summary

Researchers developed crystalline poly(L-lactide) nanoparticles from nanofibers. These nanoparticles can be functionalized with fluorescent dyes, showing potential for bioimaging and nanomedicine.

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Area of Science:

  • Materials Science
  • Polymer Chemistry
  • Nanotechnology

Background:

  • Poly(L-lactide) (PLLA) is a biodegradable and biocompatible polymer.
  • Electrospinning is a versatile technique for fabricating polymer nanofibers.
  • Developing functional nanoparticles from existing polymer structures is of interest for biomedical applications.

Purpose of the Study:

  • To prepare crystalline poly(L-lactide) (PLLA) nanoparticles from electrospun PLLA nanofibers.
  • To control nanoparticle size and surface functionality for potential applications.
  • To investigate the crystallinity and modification of the resulting nanoparticles.

Main Methods:

  • Aminolysis of electrospun PLLA nanofibers.
  • Control of nanoparticle size via reaction conditions or fiber diameter.
Keywords:
AMINOLYSISELECTROSPINNINGFLUORESCENT LABELINGNANOPARTICLESPOLY(L -LACTIDE)

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  • Characterization using X-ray diffraction (XRD) and differential scanning calorimetry (DSC).
  • Molecular weight determination using gel-permeation chromatography (GPC).
  • Surface functionalization via amine group reaction with isothiocyanate groups.

    • Main Results:

    • Crystalline PLLA nanoparticles were successfully prepared with controllable sizes.
    • Nanoparticle crystallinity was confirmed by XRD and DSC, showing the α-form.
    • Amine groups were generated on the nanoparticle surface after aminolysis.
    • Fluorescein-5'-isothiocyanate was successfully attached to the nanoparticles.
    • Smaller nanoparticles exhibited higher fluorescein binding density.

    Conclusions:

    • A 'top-down' approach allows for the creation of tailorable PLLA nanoparticles.
    • The generated nanoparticles possess surface amine groups for further functionalization.
    • These functionalized nanoparticles show promise for bioimaging and nanomedicine applications.