Preparation and evaluation of celecoxib transdermal patches

Celecoxib Transdermal patches were prepared by using different polymers such as hydroxyl-propylmethylcellulose (HPMC), methylcellulose (MC), Polyvinylpyrolidone (PVP). The in-vitro release of the drug from the formulations were studied using commercial semi permeable membrane. The prepared formulation were subjected to various physicochemical evaluation test, in-vitro dissolution studies, kinetics studies shows diffusion might be one of the prominent mechanism influencing the drug release. To confirm the fact Peppa's plot was drawn, which confirmed that the diffusion mechanism involved in the drug release was of non fickian diffusion type. ex-vivo diffusion studies by using rat skin, guinea pig skin and pig ear skin and finally in-vivo evaluation studies (the patch F4 HPMC 0.75%, PVP 0.25%) were carried out by using rabbits.