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Updated: Jun 12, 2026
09:25
Quantifying Subcellular Ubiquitin-proteasome Activity in the Rodent Brain
Published on: May 21, 2019
The ubiquitin-proteasome pathway and synaptic plasticity.
1Department of Neurobiology and Anatomy, Wake Forest University Health Sciences, Winston-Salem, North Carolina 27157, USA.
Learning & Memory (Cold Spring Harbor, N.Y.)
|June 23, 2010
Summary
The ubiquitin-proteasome pathway (UPP) regulates brain functions like synaptic plasticity. This pathway
Area of Science:
- Neuroscience
- Molecular Biology
- Cell Biology
Background:
- The ubiquitin-proteasome pathway (UPP) is crucial for protein degradation.
- UPP controls essential neuronal functions, including synaptic plasticity.
- Neuronal UPP activity is locally regulated within different cellular compartments.
Purpose of the Study:
- To provide an overview of the UPP's role in synaptic plasticity.
- To highlight the localized functions and regulation of UPP in neurons.
Main Methods:
- Review of existing literature on the ubiquitin-proteasome pathway in neuroscience.
- Analysis of studies investigating UPP in invertebrate and vertebrate model systems.
Main Results:
- UPP regulates key synaptic proteins, receptors, kinases, and transcription factors.
- Evidence suggests non-uniform UPP operation across neuronal subcompartments.
- Local enzymes for ubiquitination and deubiquitination, and proteasome functions vary within neurons.
Conclusions:
- The UPP plays a significant role in synaptic plasticity.
- Local regulation of UPP components and proteasome activity is critical for neuronal function.
- Understanding localized UPP mechanisms is key to comprehending synaptic plasticity.
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In this pathway, the target proteins are first tagged with small proteins called ubiquitin. This involves participation of a series of enzymes including— E1 (ubiquitin-activating enzyme), E2 (ubiquitin-conjugating enzyme), and E3 (ubiquitin...
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In this pathway, the target proteins are first tagged with small proteins called ubiquitin. A series of enzymes carry out the ubiquitination of the target proteins - E1 (ubiquitin-activating enzyme), E2 (ubiquitin-conjugating enzyme), and E3...
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01:01Neuroplasticity
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