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Updated: Jun 12, 2026
07:17
Phenotypic and Functional Analysis of Activated Regulatory T Cells Isolated from Chronic Lymphocytic Choriomeningitis Virus-infected Mice
Published on: June 22, 2016
Control of Th2-mediated inflammation by regulatory T cells
K Venuprasad1, K Venuprasad Poojary, Yi-Chi M Kong
1Karmanos Cancer Institute and Department of Immunology and Microbiology, Wayne State University, Detroit, Michigan, USA. poojaryv@karmanos.org
The American Journal of Pathology
|June 23, 2010
Summary
Regulatory T cells (Tregs) are crucial for immune tolerance in allergic diseases like asthma. Strategies to induce allergen-specific Tregs show promise for preventing and treating airway inflammation.
Area of Science:
- Immunology
- Allergy and Asthma Research
Background:
- Allergic diseases and asthma stem from imbalanced Th2 immune responses.
- Immune tolerance is key to preventing respiratory allergic reactions.
- Foxp3+ regulatory T cells (Tregs) are vital for immune tolerance and controlling Th2 responses.
Purpose of the Study:
- To explore the role of regulatory T cells (Tregs) in the development and prevention of allergic diseases.
- To investigate the potential of inducing allergen-specific Tregs for asthma treatment.
Main Methods:
- The study reviews existing evidence on Treg development and function.
- It discusses the link between Treg impairment and increased susceptibility to allergies.
- Focuses on the therapeutic potential of allergen-specific Tregs.
Main Results:
- Tregs, both natural and induced, are critical for maintaining immune tolerance.
- Dysfunctional Tregs are associated with heightened allergy and airway inflammation.
- Inducing allergen-specific Tregs is a promising therapeutic strategy.
Conclusions:
- Restoring or enhancing Treg function is a viable approach for managing allergic diseases.
- Targeting Treg induction could lead to novel treatments for asthma and related conditions.
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