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Related Experiment Video

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Tissue Engineering of the Intestine in a Murine Model

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Emerging therapies for intestinal failure.

Kelly A Tappenden¹

¹Department of Food Science and Human Nutrition, University of Illinois at Urbana-Champaign, 443 Bevier Hall, 905 S Goodwin Ave, Urbana, IL 61821, USA. tappende@illinois.edu

Archives of Surgery (Chicago, Ill. : 1960)

|June 23, 2010

Summary

Butyrate supplementation in parenteral nutrition stimulates intestinal adaptation in patients with intestinal failure. This finding offers a potential strategy to reduce long-term parenteral nutrition dependence and its complications.

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Effect of Hyaluronic Acid 35 kDa on an In Vitro Model of Preterm Small Intestinal Injury and Healing Using Enteroid-Derived Monolayers

Effect of Hyaluronic Acid 35 kDa on an In Vitro Model of Preterm Small Intestinal Injury and Healing Using Enteroid-Derived Monolayers

Published on: July 28, 2022

Area of Science:

Gastroenterology
Nutritional Science
Surgical Research

Background:

Intestinal failure presents significant challenges, necessitating effective intestinal rehabilitation therapies.
Massive small-bowel resection triggers compensatory adaptation in the remaining intestine.
Parenteral nutrition (PN), while life-sustaining, can impede adaptation and cause mucosal atrophy due to lack of oral/enteral stimulation.

Purpose of the Study:

To investigate the potential of butyrate, a short-chain fatty acid, to enhance intestinal adaptation during PN.
To explore strategies for optimizing PN regimens to improve outcomes for patients with intestinal failure.

Main Methods:

Administration of parenteral nutrition supplemented with butyrate.
Assessment of structural and functional intestinal adaptation.
Evaluation of mucosal changes and response to PN.

Main Results:

Butyrate addition to PN significantly stimulated intestinal adaptation.
The findings suggest a positive role for butyrate in counteracting PN-induced mucosal atrophy.
Supplementation demonstrated potential to improve the efficacy of PN in intestinal rehabilitation.

Conclusions:

Butyrate is a promising therapeutic agent for enhancing intestinal adaptation in patients on PN.
Formulating PN with butyrate may reduce long-term dependence on PN for individuals with intestinal failure.
This approach could mitigate complications associated with prolonged PN therapy.