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Pinocembrine: a bioactive flavanone from Teloxys graveolens
M Del Rayo Camacho1, B Sanchez, H Quiroz
1Division de Bioquimica y Farmacia, Facultad de Quimica, Universidad Nacional Autonoma de Mexico, Mexico D.F.
Journal of Ethnopharmacology
|March 1, 1991
Summary
The plant Teloxys graveolens contains 5,7-dihydroxyflavanone (pinocembrine), a compound with potent bioactivity. This natural product demonstrates significant fasciolicidal, ovicidal, and larvicidal properties against various parasites.
Area of Science:
- Pharmacognosy
- Natural Product Chemistry
- Parasitology
Background:
- Teloxys graveolens (Willd.) Weber (Chenopodiaceae) is a plant species with potential medicinal properties.
- Natural products are a rich source of bioactive compounds for therapeutic development.
- Parasitic infections caused by Fasciola hepatica, Ascaridi galli, and Stomoxys calcitrans pose significant health and economic challenges.
Purpose of the Study:
- To isolate and identify bioactive compounds from Teloxys graveolens.
- To evaluate the antiparasitic activities of isolated compounds.
- To explore the potential of natural products in combating parasitic infections.
Main Methods:
- Bioactivity-directed fractionation of the acetone extract of Teloxys graveolens.
- Brine shrimp lethality assay for cytotoxicity and bioactivity screening.
- Determination of lethal concentration 50 (LC50) for the isolated compound.
- In vitro testing of the isolated compound against Fasciola hepatica, Ascaridi galli, and Stomoxys calcitrans.
Main Results:
- 5,7-dihydroxyflavanone (pinocembrine) was isolated as the sole active compound from the plant extract.
- Pinocembrine exhibited significant bioactivity with a lethal concentration 50 (LC50) of 4.25 micrograms/ml in the brine shrimp lethality test.
- The isolated pinocembrine demonstrated fasciolicidal, ovicidal, and larvicidal activities against Fasciola hepatica, Ascaridi galli, and Stomoxys calcitrans, respectively.
Conclusions:
- Teloxys graveolens contains the bioactive flavanone, pinocembrine.
- Pinocembrine possesses significant antiparasitic properties, indicating its potential as a natural therapeutic agent.
- Further research into pinocembrine could lead to novel treatments for parasitic diseases.