Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jun 12, 2026

Transplantation of Olfactory Ensheathing Cells to Evaluate Functional Recovery after Peripheral Nerve Injury
10:33

Transplantation of Olfactory Ensheathing Cells to Evaluate Functional Recovery after Peripheral Nerve Injury

Published on: February 23, 2014

Experience with nerve allograft transplantation.

Ida K Fox1, Susan E Mackinnon

  • 1Division of Plastic Surgery, Washington University School of Medicine, Saint Louis, Missouri.

Seminars in Plastic Surgery
|June 23, 2010
PubMed
Summary

Nerve allograft transplantation offers a solution for severe nerve injuries when other methods fail. Research is ongoing to reduce rejection risks and improve nerve regeneration for better patient outcomes.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Functional connectivity during drawing after upper extremity peripheral nerve surgery: enhanced connectivity between motor and visuomotor-parietal regions.

bioRxiv : the preprint server for biology·2026
Same author

Commentary: Quantitative Scratch Collapse Test Methodology with Handheld Dynamometer: Normative Upper-Extremity Force Data and Reliability Analysis.

Journal of hand surgery global online·2026
Same author

Commentary: Neurapraxia in Time and Space.

Neurosurgery·2026
Same author

Intraindividual Limb Comparisons of Motor and Neurophysiological Outcomes Using the European Multicenter Study About Spinal Cord Injury: Implications for Clinical Trials in Acute Cervical Spinal Cord Injury.

Journal of neurotrauma·2026
Same author

Modulation of the regenerative microenvironment within acellular nerve allografts using tacrolimus improves nerve regeneration.

Neural regeneration research·2026
Same author

Surgeons, physiatrists and neurologists speaking "EDX and nerve surgery": A paradigm shift for nerve injured patients.

JPRAS open·2026

Area of Science:

  • Regenerative medicine
  • Transplantation immunology
  • Neuroscience

Background:

  • Peripheral nerve injuries often require complex reconstructive procedures.
  • Autologous nerve grafting and nerve transfers have limitations for severe injuries.
  • Nerve allograft transplantation presents an alternative but faces challenges with immunogenicity and immunosuppression.

Purpose of the Study:

  • To explore the potential of nerve allograft transplantation for unreconstructable peripheral nerve injuries.
  • To review advancements in nerve allograft preservation and immunosuppression.
  • To identify future research directions for optimizing nerve allograft outcomes.

Main Methods:

  • Review of translational research in nerve allograft transplantation.
Keywords:
Peripheral nerveallografttransplantation

Related Experiment Videos

Last Updated: Jun 12, 2026

Transplantation of Olfactory Ensheathing Cells to Evaluate Functional Recovery after Peripheral Nerve Injury
10:33

Transplantation of Olfactory Ensheathing Cells to Evaluate Functional Recovery after Peripheral Nerve Injury

Published on: February 23, 2014

  • Analysis of methods for allograft cold preservation (e.g., University of Wisconsin solution).
  • Evaluation of immunosuppressive regimens including tacrolimus.

    • Main Results:

    • Nerve allograft transplantation is a viable option for severe nerve injuries.
    • Preoperative cold preservation and tacrolimus-based immunosuppression are key advancements.
    • Strategies to reduce immunogenicity and enhance neuroregeneration are under investigation.

    Conclusions:

    • Nerve allograft transplantation holds promise for challenging peripheral nerve injuries.
    • Minimizing immunosuppression and promoting nerve regeneration are critical for clinical success.
    • Further research aims to improve functional recovery and reduce patient morbidity.