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Updated: Jun 12, 2026

An Orthotopic Sciatic Nerve Xenograft for Neurofibromatosis Type 1 Neurofibromas
Published on: October 10, 2025
A rare case of segmental neurofibromatosis involving the sciatic nerve
Aron Trocchia1, Alma Reyes, Jon Wilson
1Department of Orthopaedics, William Beaumont Hospital, Royal Oak, Michigan 48073, USA. aron@drexel.edu
Abstract:
Segmental neurofibromatosis (NF-5) is an extremely rare variant of neurofibromatosis involving a single extremity without pathologic features beyond the midline. A case of segmental neurofibromatosis involving the sciatic nerve and its branches is presented with a detailed description of the patient's preoperative findings plus postoperative course through 1-year follow-up. Clinical, histologic, and genetic findings are given along with a brief review of the literature on segmental neurofibromatosis. Last, treatment options and postoperative care recommendations are provided.
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