Ultraviolet recall dermatitis reaction with sorafenib

Area of Science:

• Dermatology
• Oncology
• Pharmacology

Background:

• Recall dermatitis is a rare, poorly understood drug reaction.
• Phototoxic reactions, triggered by sunlight or UV, are known with certain drugs like chemotherapy agents and antibiotics.

Observation:

• A patient with renal cell carcinoma experienced an acute skin reaction on their hands after sun exposure.
• This eruption occurred four weeks after discontinuing sorafenib treatment.

Findings:

• The reaction mimicked a previous skin issue the patient had while on sorafenib.
• The localized, well-demarcated erythematous and papulomatous eruption was triggered by solar exposure.

Implications:

• This is the first reported case of sorafenib-induced photo-induced recall dermatitis.
• The positive response to corticosteroids suggests a significant role for the immune system in photo-recall reactions.