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Continuous Liquid-Liquid Extraction of Medium-Chain Fatty Acids from Fermentation Broth Using Hollow-Fiber Membranes
Published on: August 9, 2024
Multimembrane bioreactor for extractive fermentation
1School of Chemical Engineering Cornell University Ithaca, NY 14853.
Abstract:
A multimembrane reactor is described. Four layers (gas, cells, nutrient, and solvent) are separated by membranes. This structure prevents solvent emulsification in the fermentation broth. The system was tested for ethyl alcohol production from glucose using yeast. Tributyl phosphate (TBP) was chosen as the extractant. Experiments demonstrate for the first time a successful extractive fermentation with a practical solvent. Prevention of emulsification removes the toxic effect of TBP on yeast metabolism.
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