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Updated: Jun 12, 2026

Supercritical Nitrogen Processing for the Purification of Reactive Porous Materials
Published on: May 15, 2015
Evaluation of supercritical fluid extraction in the pharmaceutical industry
1Merck Sharp & Dohme Research Laboratories P.O. Box 2000 Rahway, New Jersey 07065.
Abstract:
Various steroids precipitate from supercritical CO(2) as very small particles but still retain their crystallinity. This suggests that SCFE in this industry could be utilized as a size reduction method as an alternative to milling. The application of SCFE as a separation technique is demonstrated by the simultaneous extraction and reaction of mevinolin, a metabolite of the fungus Aspergillus terreus.
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