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Related Experiment Videos

Are bisphosphonates ready for the adjuvant setting?

Larissa A Korde1, Julie R Gralow

  • 1Division of Oncology, University of Washington and Seattle Cancer Care Alliance, Seattle, Washington 98119, USA. lkorde@u.washington.edu

Oncology (Williston Park, N.Y.)
|June 24, 2010
PubMed
Summary

No abstract available in PubMed .

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Pharmacological management
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5-HT3 receptor antagonists, such as dolasetron, granisetron (Kytril), ondansetron (Zofran), and palonosetron (Axoli), are crucial in managing chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea. These drugs selectively block 5-HT3 receptors in the visceral vagal and spinal afferent nerves, chemoreceptor trigger zone, and the vomiting center. They have a rapid onset of action and can be given as a single dose before chemotherapy. Ondansetron and granisetron, in particular,...

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