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Icb-1 Gene expression is elevated in human endometrial adenocarcinoma and is closely associated with HER2 expression
Anette Springwald1, Claus Lattrich, Maciej Skrzypczak
1Department of Obstetrics and Gynecology, University Medical Center Regensburg, Germany.
Abstract:
Human gene icb-1 (C1orf38) has been initially cloned by our group from endometrial adenocarcinoma cells. In this study, we examined icb-1 expression in 90 endometrial cancer and normal endometrial tissue specimens. Expression of icb-1 was significantly (about 3.5-fold) higher in endometrial cancer than in normal endometrium (p <.0001). Determination of various molecular markers revealed that only Ki-67 expression differed between both groups in a similarly significant manner. Furthermore, we observed a highly significant positive correlation of icb-1 transcript levels with c-erbB2 (HER2) expression (p <.0001). Our data strongly encourage further studies on the function of icb-1 in endometrial cancer.
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