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Published on: August 27, 2021
Autologous melanocyte-keratinocyte suspension in the treatment of vitiligo
B M El-Zawahry1, N S Zaki, D A Bassiouny
1Department of Dermatology, Faculty of Medicine, Kasr El-Aini University Hospital, Cairo University, Cairo, Egypt.
Background:
In stable vitiligo, several techniques of autologous transplantation of melanocytes are used. Autologous melanocyte transplantation of non-cultured melanocytes is one of those techniques with variable reported outcomes.
Objective:
The objective of this study was to evaluate the response to autologous melanocyte-keratinocytes suspension transplantation in cases of stable vitiligo.
Methods:
A total of 25 cases of vitiligo were treated by autologous melanocyte-keratinocytes suspension transplantation. After 6-17 months, patients' response was evaluated according to the extent of pigmentation (excellent 90-100%, good 50-89%, fair 20-49% and poor response <20%).
Results:
Of the 25 patients treated, 22 continued the follow-up period. Five (23%) patients showed excellent response, 7 (32%) good, 6 (27%) fair and 4(18%) showed poor response.
Conclusion:
Unlike transplantation of cultured melanocytes, which requires experience in culture technique, autologous melanocyte-keratinocytes suspension transplantation is an easy economic technique, which may be used in resistant areas of stable vitiligo.
