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Updated: Jun 12, 2026

The Helsinki Rat Microsurgical Sidewall Aneurysm Model

The Helsinki Rat Microsurgical Sidewall Aneurysm Model

Published on: October 12, 2014

An experimental aneurysm model: a training model for neurointerventionalists.

I Q Grunwald¹, B Romeike, R Eymann

¹Department for Neuroradiology, University of the Saarland; Germany.

Interventional Neuroradiology : Journal of Peritherapeutic Neuroradiology, Surgical Procedures and Related Neurosciences

|June 24, 2010

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This study developed a reproducible rabbit model for testing aneurysm treatments and interventional training. The model successfully created aneurysms and demonstrated high occlusion rates with GDC-Coils, showing promise for device evaluation and procedural skill development.

Area of Science:

Vascular Surgery
Interventional Radiology
Pre-clinical Research

Background:

Reproducible animal models are crucial for evaluating aneurysm therapies.
Such models also aid in training for complex interventional procedures.

Purpose of the Study:

To establish a reliable animal model for testing endovascular aneurysm occlusion techniques.
To assess the efficacy of GDC-Coils for aneurysm embolization.
To evaluate the model's utility for interventional training.

Main Methods:

Aneurysms were created in 35 New Zealand White rabbits using elastase infusion.
Endovascular embolization was performed using GDC-Coils in 27 aneurysms.
Microcatheter placement times were recorded for professionals, semi-professionals, and trainees.

Related Experiment Videos

Last Updated: Jun 12, 2026

The Helsinki Rat Microsurgical Sidewall Aneurysm Model

The Helsinki Rat Microsurgical Sidewall Aneurysm Model

Published on: October 12, 2014

Angiographic and histological assessments evaluated occlusion rates and long-term outcomes.

Main Results:

Aneurysms (2-6 mm) were reliably created in all rabbits.
An average angiographic occlusion rate of 89.5% was achieved.
Histology confirmed no recanalization in embolized aneurysms, while controls remained patent.
Trainees showed significant improvement in catheter placement time, nearing professional proficiency.

Conclusions:

The rabbit model is effective for pre-clinical assessment of aneurysm therapies and endovascular devices.
This model provides a valuable platform for training interventionalists in aneurysm occlusion techniques.
The model allows for evaluation of embolization devices, long-term prognosis, and device effects.