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Related Experiment Videos

Cisplatin ototoxicity in children: a practical grading system.

P R Brock1, S C Bellman, E C Yeomans

  • 1Department of Haematology and Oncology, Hospitals for Sick Children, London, England.

Medical and Pediatric Oncology
|January 1, 1991
PubMed
Summary

Cisplatin chemotherapy for childhood cancers can cause significant hearing loss, with half of patients experiencing moderate to severe effects. Hearing loss did not improve over time, highlighting the need for careful monitoring during treatment.

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Area of Science:

  • Pediatric Oncology
  • Audiology
  • Ototoxicology

Background:

  • Cisplatin is a cornerstone chemotherapy agent for various childhood malignancies.
  • Ototoxicity is a known, dose-dependent side effect of cisplatin treatment.
  • Long-term hearing outcomes in pediatric cancer survivors treated with cisplatin require further investigation.

Purpose of the Study:

  • To assess the long-term ototoxicity in children treated with standard-dose cisplatin for malignant tumors.
  • To propose a practical grading system for cisplatin-induced hearing loss.
  • To identify risk factors and long-term hearing recovery patterns.

Main Methods:

  • A long-term follow-up study involving children at least 2 years post-cisplatin treatment.
  • Hearing assessment using pure-tone audiometry.

Related Experiment Videos

  • Development and application of a 0-4 grading system for hearing loss.

    • Main Results:

    • Half of the children experienced moderate to severe high-frequency hearing loss (grade 2-4).
    • Ten children required hearing aids due to significant hearing impairment.
    • Cumulative cisplatin dose was a significant risk factor for ototoxicity (P = 0.027).
    • No hearing recovery was observed in serial follow-up tests up to 4 years post-treatment.

    Conclusions:

    • Standard-dose cisplatin therapy poses a substantial risk of long-term ototoxicity in children.
    • A practical grading system for hearing loss is proposed for clinical use.
    • Close audiological monitoring is recommended during cisplatin treatment, especially with cumulative doses exceeding 400 mg/m2.
    • Consideration of alternative chemotherapy is advised upon development of grade 2 ototoxicity.