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Related Concept Videos

Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

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The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
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Role of Skin in Vitamin D Synthesis01:23

Role of Skin in Vitamin D Synthesis

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The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
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Skin Cancer01:30

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Pigmentation01:19

Pigmentation

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The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
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Skin Diseases and Disorders01:23

Skin Diseases and Disorders

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
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Sensory Functions of the Skin01:16

Sensory Functions of the Skin

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The skin is the largest organ of the human body and plays a crucial role in our sensory perception. It contains a vast network of sensory receptors that contribute to the skin's protective function by perceiving physical, biological, and environmental cues and generating relevant responses.
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Transcription from the thyroid hormone-dependent promoter of the Xenopus laevis thyroid hormone receptor betaA gene requires a novel upstream element and the initiator, but not a TATA Box.

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Related Experiment Video

Updated: Feb 28, 2026

Author Spotlight: Enhancing Skin Model Diversity with Cost-Effective 3D Cellular Models
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[New views about the skin].

J-C Guimberteau1, J-P Delage, J Wong

  • 1Institut Aquitain de la main, Bordeaux-Pessac, France. adf.guimberteau@wanadoo.fr

Annales De Chirurgie Plastique Et Esthetique
|June 24, 2010
PubMed
Summary

This study explores the skin's subcutaneous architecture, revealing how microvacuolar and multifibrillar arrangements enable tissue mobility and structural integrity. Understanding these dynamic systems is key to comprehending skin's response to body movement.

Area of Science:

  • Dermatology and Anatomy
  • Tissue Engineering and Biomechanics

Context:

  • Follow-up to "Introduction to the knowledge of subcutaneous sliding system in humans."
  • Investigates skin architecture and subcutaneous multifibrillar/microvacuolar arrangements.
  • Utilizes high-resolution endoscopic observations during live surgery.

Purpose:

  • To highlight the direct link between the skin and subcutaneous environment in dynamic living tissue.
  • To reveal how microvacuolar and microspaces provide dynamic structure and form during movement.
  • To understand the morphodynamics necessary for tissue mobility and continuity.

Summary:

  • Skin's polyhedric surface design correlates with underlying multifibrillar pillars, dictating patterning and movement.
  • Chaotic, fractal organization of multifibrils and cellular components ensures tissue continuity.

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  • Hydration state influences the characteristics of these interlaced structures.

    • Impact:

    • Provides insight into the integral arrangement responsible for structures below the skin.
    • Enhances understanding of how skin behaves in relation to overall body movement.
    • Contributes to knowledge of skin's form, mobility, adaptability, and resistance to gravity.