[Effect of vitamin D deficiency on cardiovascular risk]
C Cormier1, M Courbebaisse, E Maury
1Service de rhumatologie, hôpital Cochin, AP-HP, université Paris Descartes, 27, rue du Faubourg-Saint-Jacques, 75014 Paris, France. catherine.cormier@cch.aphp.fr
Abstract:
Vitamin D deficiency affects almost 50 % of the population worldwide. Besides its classical effects on bone and calcium metabolism, vitamin D displays a wide spectrum of non classical effects. Among these effects, those targeting the cardiovascular system are mostly documented by observational, experimental and small intervention trials that most often evaluated intermediate parameters. The time has now come for large placebo-controlled trials targeting clinical endpoints such as the incidence of major cardiovascular events and mortality.
Insights
Vitamin D deficiency is common globally. Emerging research highlights vitamin D
Area of Science:
- Endocrinology and Metabolism
- Cardiovascular Science
Context:
- Vitamin D deficiency impacts nearly 50% of the global population.
- Beyond bone health, vitamin D has diverse non-classical effects.
Purpose:
- To investigate the non-classical cardiovascular effects of vitamin D.
- To emphasize the need for large-scale trials on clinical cardiovascular endpoints.
Summary:
- Observational and small intervention studies suggest vitamin D influences cardiovascular health.
- Current evidence often relies on intermediate parameters rather than clinical outcomes.
Impact:
- Highlights the need for robust clinical trials to confirm vitamin D's role in cardiovascular disease prevention.
- Suggests a shift towards evaluating major cardiovascular events and mortality in vitamin D research.
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