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Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis

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Reproductive patterns in psychotic patients.

T M Laursen¹, T Munk-Olsen

¹National Centre for Register-Based Research, Aarhus University, Taasingegade 1, 8000 Aarhus C, Denmark. tml@ncrr.dk

Schizophrenia Research

|June 24, 2010

Summary

Individuals with severe mental health conditions like schizophrenia have significantly lower fertility rates compared to the general population. Fertility increases with time since disorder onset, suggesting a selection process for less severe cases becoming parents.

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Area of Science:

Psychiatric Epidemiology
Reproductive Health
Mental Disorder Outcomes

Background:

Longitudinal studies indicate poorer outcomes for individuals with psychotic disorders compared to the general population.
Reproductive patterns, measured by fertility rates, serve as a proxy for well-being following psychotic disorder onset.

Purpose of the Study:

To compare fertility rates in patients with schizophrenia and bipolar disorder against other psychiatric patients and the general population.
To investigate the influence of parental status at disease onset, time since onset, and abortion rates on reproductive patterns.

Main Methods:

A prospective, register-based cohort study utilizing the entire Danish population born after 1950.
Fertility rates were analyzed using survival analysis to calculate Incidence Rate Ratios (IRRs).

Main Results:

Schizophrenia patients exhibited the lowest fertility rates: IRR=0.10 for men and IRR=0.18 for women.
Bipolar disorder patients showed higher fertility (men IRR=0.32, women IRR=0.36) than schizophrenia patients but lower than the general population.
Fertility rates increased with longer duration since psychiatric disorder onset across all groups.

Conclusions:

A selection process exists where individuals with more severe psychiatric disorders are less likely to become parents.
Reduced fertility is significantly associated with the time elapsed since the onset of the psychiatric disorder.